𖤓 Welcome to Bolen et. al 𖤓

This repository accompanies the paper “Single-cell multiomics identifies unique features of immune dysfunction in the colon, blood and stool from individuals diagnosed with Parkinson’s disease or Inflammatory bowel disease”, presenting all analyses conducted as part of the study. Our work focuses on the relationship between Parkinson Disease(PD) and Inflammatory Bowel Disease (IBD).

☘ TECHNIQUES

We worked with Spatial Transcriptomics, and we utilized:

• Custom R pipelines
• Custom Python pipelines

📊 DATASETS

• Single-cell multiomic spatial imaging (via NanoString CosMxTM) of colonic tissue
• Akoya proteomics

✎ REPOSITORY

Here’s what you’ll find:

• /data/: Storing of data.
• /figures/: Code to reproduce all the figures of the paper.
  
• /analysis/: Code of the analysis of Spatial Transcriptomics data.